ATI LPN
LPN Pharmacology Practice Questions Questions
Question 1 of 5
A nurse is assessing a client who has been taking lithium carbonate. Which of the following findings should the nurse report to the provider?
Correct Answer: B
Rationale: The correct answer is B: Tremors. Tremors are a sign of lithium toxicity and should be reported immediately. Increased urination is a common side effect of lithium but not an urgent concern requiring immediate reporting. Weight gain is also a common side effect of lithium but does not indicate toxicity. Blurred vision is not typically associated with lithium toxicity; therefore, it is not the priority finding to report.
Question 2 of 5
The NP chooses to give cephalexin every 8 hours based on knowledge of the drug's:
Correct Answer: B
Rationale: Choice B is correct because dosing cephalexin every 8 hours aligns with its biological half-life, the time it takes for half the drug to be eliminated, ensuring steady therapeutic levels. Choice A is incorrect as ‘propensity to target receptor' isn't a standard pharmacokinetic term for dosing decisions. Choice C is wrong because pharmacodynamics (drug effects) informs efficacy, not timing. Choice D is incorrect since safety and side effects influence drug choice, not specifically the 8-hour interval.
Question 3 of 5
When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
Correct Answer: B
Rationale: Choice B is correct because synergy means the combined effect exceeds the sum of individual effects, enhancing therapeutic outcomes beyond additive results. Choice A is incorrect as it describes an additive, not synergistic, effect. Choice C is wrong because synergy doesn't reduce efficacy below individual effects. Choice D is incorrect since synergy is a predictable pharmacological principle, not entirely variable.
Question 4 of 5
Phase I oxidative-reductive processes of drug metabolism require certain nutritional elements. Which of the following would reduce or inhibit this process?
Correct Answer: A
Rationale: Choice A is correct because phase I metabolism, involving cytochrome P450 enzymes, relies on protein for enzyme synthesis; malnutrition impairs this, reducing metabolism. Choice B is incorrect as iron deficiency affects oxygen transport, not directly phase I processes. Choice C is wrong since only protein malnutrition, not iron deficiency, is directly relevant. Choice D is incorrect because protein malnutrition does impact metabolism.
Question 5 of 5
Drugs that use CYP 3A4 isoenzymes for metabolism may:
Correct Answer: C
Rationale: Choice C is correct because CYP 3A4 drugs can induce (speed up) or inhibit (slow down) metabolism of other drugs sharing this pathway, affecting their levels and efficacy. Choice A is incorrect as it's only half the story—induction happens, but inhibition does too. Choice B is wrong because it misses induction potential. Choice D is incorrect since both effects are well-documented with CYP 3A4.