A child appears with chronic cough and failure to thrive. Physical examination reveals nasal polyps and digital clubbing. Sweat chloride test is positive. Most likely diagnosis is:

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Question 1 of 5

A child appears with chronic cough and failure to thrive. Physical examination reveals nasal polyps and digital clubbing. Sweat chloride test is positive. Most likely diagnosis is:

Correct Answer: D

Rationale: Cystic fibrosis matches chronic cough, failure to thrive, polyps, clubbing, and positive sweat test, per CFF. A-C, E don’t fit.

Question 2 of 5

A 3-year-old girl presents with recurrent fractures and blue sclerae. Most likely diagnosis is:

Correct Answer: A

Rationale: Osteogenesis imperfecta causes recurrent fractures and blue sclerae, per NIH. B-E lack this combination.

Question 3 of 5

A 1-year-old girl presents with fever and a bulging fontanelle. CSF shows gram-negative bacilli. Most likely diagnosis is:

Correct Answer: B

Rationale: Bacterial meningitis fits fever, bulging fontanelle, and gram-negative bacilli, per AAP. A, C-E differ in CSF.

Question 4 of 5

A 2-month-old infant presents with jaundice and clay-colored stools. Labs show elevated direct bilirubin. Most likely diagnosis is:

Correct Answer: B

Rationale: Biliary atresia causes jaundice, clay stools, and conjugated hyperbilirubinemia, per AAP. A, C-E differ in presentation.

Question 5 of 5

A 5-year-old girl presents with fever and a vesicular rash on the scalp. Most likely diagnosis is:

Correct Answer: C

Rationale: Herpes zoster presents with a vesicular rash in a dermatome (e.g., scalp), per CDC. A, B, D, E differ in distribution.

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