A 70-year old ex-smoker stopped 4 years ago and started smoking since he was 16 years old. On average he smoked 30 cigarettes a day. What is his pack year history?

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Question 1 of 5

A 70-year old ex-smoker stopped 4 years ago and started smoking since he was 16 years old. On average he smoked 30 cigarettes a day. What is his pack year history?

Correct Answer: C

Rationale: Pack years = (cigarettes/day ÷ 20) × years smoked = (30 ÷ 20) × 50 = 75 pack years, making C the correct answer.

Question 2 of 5

A 56-year-old woman presents to discuss the results of her recent upper endoscopy. She was having some mild abdominal pain, so she underwent the procedure, which revealed an ulcer in the antrum of the stomach. Biopsy of the lesion revealed the presence of H. pylori. All of the following statements regarding her condition are correct except

Correct Answer: B

Rationale: H. pylori is thought to be responsible for a majority of cases of peptic ulcer disease. It has been associated with MALT as well as adenocarcinoma. Triple drug therapy has been shown to be more effective than dual therapy. With adequate treatment, reinfection is rare. Although urea breath testing is probably a better tool for diagnosis of active infection and adequacy of treatment, quantitative serology can be used to monitor treatment efficacy. A $30 \%$ fall in IgG titer should be seen after therapy.

Question 3 of 5

A 65-year-old man reports that he frequently regurgitates food several hours after eating, and experiences chest pain and dysphagia to both liquids and solids. This has been associated with weight loss. He has no other medical problems. A CXR shows an air/fluid level in a dilated esophagus and an absent gastric air bubble. No mass in the distal esophagus or proximal stomach is identified at the time of endoscopy. The best therapy for this patient is

Correct Answer: B

Rationale: The patient has primary achalasia, with typical CXR findings. The upper endoscopy has ruled out secondary achalasia, in that no mass was detected at the GE junction or cardia. The best treatment for this patient is endoscopic balloon dilatation, to stretch the LES, and disrupt muscle fibers. This therapy remains the mainstay for most patients with achalasia, although surgical myotomy and injection of botulinum toxin are also used.

Question 4 of 5

Which of the following statements regarding pancreatic cancer is correct?

Correct Answer: C

Rationale: Although serum CA 19-9 is not a useful screening tool in asymptomatic patients, it is quite sensitive and specific in patients with symptoms of the disease. Tumors arising from the tail or body of the pancreas are usually associated with a poorer prognosis and these patients are rarely resectable. A palpable gallbladder (Courvoisier's sign) has been described as being suggestive of a tumor at the head of the pancreas but not the tail. This sign lacks specificity, however.

Question 5 of 5

A 32-year-old woman with a one-year history of ulcerative colitis involving her whole colon presents with a one-week history of severe abdominal pain and bloody diarrhea about 10 times per day. Her heart rate is $95 / \mathrm{min}$, blood pressure 100/60, temperature $37.4^{\circ} \mathrm{C}$. Abdominal exam reveals mild abdominal distention with bowel sounds. Stool culture is negative for infection. The patient is admitted and treated with intravenous corticosteroids and oral mesalamine. Her abdominal x-ray reveals a cecal diameter of $10 \mathrm{~cm}$. Seventy-two hours after admission her symptoms have minimally improved; she is having about eight episodes of bloody diarrhea, but still has constant abdominal pain, and her examination and abdominal x-ray findings are unchanged. Which of the following options would be inappropriate?

Correct Answer: B

Rationale: Narcotics are contraindicated in the setting of toxic megacolon, as are anticholinergics and other agents that may adversely affect colonic tone such as may occur with hypokalemia or hypomagnesemia. Narcotics decrease colonic transit and can result in increased colonic dilatation and the risk of colonic perforation. Emergent colectomy is indicated in the setting of toxic megacolon if warning features occur such as increasing colon diameter, abdominal distention or decreasing bowel sounds. Even prior to such warning symptoms developing, patients often undergo colectomy in the setting of toxic megacolon if corticosteroids fail to induce remission as ultimately, approximately half of affected patients ultimately require colectomy even when other medical therapies such as cyclosporine induces remission. One week of intravenous cyclosporine induces remission in one half to two thirds of patients with severe ulcerative colitis. Infliximab is better known for its effectiveness in inducing remission in patients with Crohn's disease, but recent studies demonstrate similar effectiveness in treating acute severe ulcerative colitis.

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