A 62-year-old man presents complaining of abdominal pain and diarrhea. He notes that the symptoms have been going on for three months now and he has lost about 20 pounds over that span. He also complains of migratory arthralgias for the past year. He denies any past medical history. He never smoked cigarettes and drinks about two beers per week. He denies use of illicit drugs. A review of records from an evaluation done by another physician reveals a normal thyroid-stimulating hormone level, negative ANA, a normal sedimentation rate, and a negative HIV test. He had a flexible sigmoidoscopy done, which failed to reveal any abnormalities. You refer him for upper endoscopy and a duodenal biopsy is done, which reveals extensive PAS-positive material in the lamina propria and villous atrophy. What is the most appropriate therapy for this patient?

Correct Answer: D

Rationale: This man presents with the hallmarks of Whipple's disease (i.e., abdominal pain, diarrhea, weight loss, and arthralgias). His workup has made the diagnoses of thyroid disease, HIV, inflammatory bowel disease, and collagen vascular diseases unlikely. His small bowel biopsy is consistent with changes seen in Whipple's disease. Electron microscopy of the specimen should be able to identify the Whipple bacillus. In contrast, the pathologic findings in celiac disease include decreased villous height to crypt depth, decreased epithelial surface cell height, and increased lymphocytic infiltration of the mucosa. PAS-positive material in the lamina propria is not seen. The treatment for Whipple's disease is one year of trimethoprim/sulfamethoxazole. A gluten-free diet would be used for celiac disease. A lactose-free diet is indicated for patients with lactose intolerance. Cholestyramine is used for patients with bile acid diarrhea, usually in the setting of ileal disease. Prednisone can be used in some cases of inflammatory bowel disease and refractory celiac sprue but is not appropriate for Whipple's.

Correct Answer: A

Rationale: Helicobacter pylori infection is the most common cause of PUD, as it damages the protective mucosal lining of the stomach and duodenum, leading to ulcer formation.

Correct Answer: B

Rationale: Sucralfate forms a protective coating over ulcers, shielding them from acid and pepsin, thus aiding healing.

Correct Answer: D

Rationale: High dairy intake is not a typical cause of PUD; NSAIDs, H. pylori, and alcohol are well-established contributors to mucosal damage.

Correct Answer: B

Rationale: Eradicating H. pylori, confirmed by follow-up testing, is a key outcome of effective PUD treatment, addressing a primary cause.