A 46-year-old woman has hirsutism, hyperglycemia, obesity, muscle wasting, and increased circulating levels of adrenocorticotropic hormone (ACTH). The most likely cause of her symptoms is

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Question 1 of 5

A 46-year-old woman has hirsutism, hyperglycemia, obesity, muscle wasting, and increased circulating levels of adrenocorticotropic hormone (ACTH). The most likely cause of her symptoms is

Correct Answer: C

Rationale: This woman has the classic symptoms of a primary elevation of adrenocorticotropic hormone (ACTH) (Cushing disease). Elevation of ACTH stimulates overproduction of glucocorticoids and androgens.

Question 2 of 5

Which class(es) of hormones is/are released by exocytosis upon appropriate stimulation?

Correct Answer: D

Rationale: Peptides and catecholamines are stored in vesicles and released via exocytosis.

Question 3 of 5

do(es) not require membrane receptors to invoke cell responses.

Correct Answer: C

Rationale: Steroids diffuse into cells and bind intracellular receptors.

Question 4 of 5

Endocrine disorders resulting in too little hormone activity may stem from all of the following except

Correct Answer: C

Rationale: Reduced plasma protein binding increases free hormone levels, not decreases activity.

Question 5 of 5

The is the target for ACTH.

Correct Answer: A

Rationale: ACTH stimulates cortisol production in the adrenal cortex.

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