A 4-year-old girl presents with pallor and lethargy. Labs show hemoglobin of 6 g/dL and Howell-Jolly bodies. Most likely diagnosis is:

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Question 1 of 5

A 4-year-old girl presents with pallor and lethargy. Labs show hemoglobin of 6 g/dL and Howell-Jolly bodies. Most likely diagnosis is:

Correct Answer: B

Rationale: Sickle cell disease shows Howell-Jolly bodies, per ASH. A, C-E differ.

Question 2 of 5

A 1-month-old infant presents with cyanosis and a murmur. Echocardiogram shows transposition of the great arteries. The next step is:

Correct Answer: B

Rationale: Balloon atrial septostomy stabilizes transposition, per AHA. A-D are secondary.

Question 3 of 5

A 6-year-old boy presents with chest pain and a murmur. Echocardiogram shows aortic stenosis. The next step is:

Correct Answer: B

Rationale: Balloon valvuloplasty relieves aortic stenosis, per AHA. A, C-E depend on severity.

Question 4 of 5

A 1-month-old infant presents with jaundice and hepatomegaly. Labs show elevated GGT. Most likely diagnosis is:

Correct Answer: B

Rationale: Biliary atresia features jaundice and elevated GGT, per AAP. A, C-E differ.

Question 5 of 5

A 1-month-old infant presents with cyanosis and a murmur. Echocardiogram shows pulmonary atresia. The next step is:

Correct Answer: B

Rationale: Prostaglandin E1 maintains ductal patency in pulmonary atresia, per AHA. A, C-E follow.

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