A 23-year-old woman has a routine health status examination. Her body mass index is 22. Laboratory studies show fasting plasma glucose is 130 mg/dL. Urinalysis shows mild glucosuria, but no ketonuria or proteinuria. She has no detectable insulin autoantibodies. Her father was similarly affected at age 20 years. She is most likely to have a mutation in a gene encoding for which of the following?

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Question 1 of 5

A 23-year-old woman has a routine health status examination. Her body mass index is 22. Laboratory studies show fasting plasma glucose is 130 mg/dL. Urinalysis shows mild glucosuria, but no ketonuria or proteinuria. She has no detectable insulin autoantibodies. Her father was similarly affected at age 20 years. She is most likely to have a mutation in a gene encoding for which of the following?

Correct Answer: B

Rationale: This patient has maturity-onset diabetes of the young (MODY), which accounts for less than 5% of cases of diabetes mellitus and is linked to specific genetic defects involving islet cells and inherited in an autosomal dominant fashion. In this patient with MODY2, there is an inactivating mutation in glucokinase that increases the beta cell threshold for insulin release, and the hyperglycemia is mild.

Question 2 of 5

Which of the following hormones come from anterior lobe of the pituitary gland?

Correct Answer: B

Rationale: ACTH is from anterior pituitary; inhibin (gonads), T3 (thyroid), oxytocin and ADH (posterior pituitary) are not.

Question 3 of 5

Which is true of dark (red) muscle?

Correct Answer: A

Rationale: Dark (red) muscle is slow-twitch, rich in mitochondria, suited for endurance.

Question 4 of 5

Which of the following factors is not involved in determining cardiac output?

Correct Answer: D

Rationale: All affect CO: stretch (preload), hormones (epinephrine), ANS (sympathetic), resistance (afterload).

Question 5 of 5

Leia suffered a deep laceration (cut) to her right forearm immediately distal to her elbow and notes blood spurting from the wound. At which of the following pressure points may direct pressure be placed to slow or stop severe bleeding:

Correct Answer: D

Rationale: Brachial artery pressure point (above elbow) controls forearm bleeding.

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