A 19-year-old, previously healthy woman collapsed after complaining of a mild sore throat the previous day. On examination she is hypotensive and febrile with purpuric skin lesions. Her peripheral blood smear shows schistocytes. Imaging studies show her adrenal glands are enlarged, and there are extensive bilateral cortical hemorrhages. Infection with which of the following organisms best accounts for these findings?

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Question 1 of 5

A 19-year-old, previously healthy woman collapsed after complaining of a mild sore throat the previous day. On examination she is hypotensive and febrile with purpuric skin lesions. Her peripheral blood smear shows schistocytes. Imaging studies show her adrenal glands are enlarged, and there are extensive bilateral cortical hemorrhages. Infection with which of the following organisms best accounts for these findings?

Correct Answer: D

Rationale: This is the typical adrenal finding in Waterhouse-Friderichsen syndrome, and meningococcemia is the most likely cause of such a rapid course. Chronic adrenocortical insufficiency can result from disseminated tuberculosis and from fungal infections, such as histoplasmosis, that involve the adrenal glands.

Question 2 of 5

Which of the following is a valve that contains 2 cusps and allows blood to flow into a ventricle?

Correct Answer: D

Rationale: Mitral (bicuspid) valve has 2 cusps, allows flow from left atrium to ventricle.

Question 3 of 5

Which of the following can increase blood flow?

Correct Answer: A

Rationale: Larger diameter reduces resistance (F = P/R), increasing flow; others impede it.

Question 4 of 5

Calculate the net filtration pressure (NFP) with a capillary hydrostatic pressure (CHP) of 20 mm Hg and a blood colloid oncotic pressure (BCOP) of 25 mm Hg. Then determine if filtration or reabsorption occurs.

Correct Answer: D

Rationale: NFP = CHP - BCOP = 20 - 25 = -5 mm Hg; negative NFP means reabsorption.

Question 5 of 5

Which of the following structures protects the lower respiratory system from food and fluid bolus during swallowing?

Correct Answer: B

Rationale: Epiglottis closes over glottis during swallowing to prevent aspiration.

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