A 15-year-old girl with a history of cystic fibrosis appears with polydipsia and polyuria for the past 2 months. Laboratory findings reveal blood glucose of 250 mg/dL. Most likely diagnosis is:

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Question 1 of 5

A 15-year-old girl with a history of cystic fibrosis appears with polydipsia and polyuria for the past 2 months. Laboratory findings reveal blood glucose of 250 mg/dL. Most likely diagnosis is:

Correct Answer: C

Rationale: Cystic fibrosis-related diabetes fits polydipsia, polyuria, and hyperglycemia in cystic fibrosis, per CFF. A, B, D, E are less likely.

Question 2 of 5

A 2-week-old infant presents with jaundice and poor feeding. Labs show direct bilirubin of 5 mg/dL. The next step is:

Correct Answer: C

Rationale: Abdominal ultrasound evaluates conjugated hyperbilirubinemia (direct bilirubin >2 mg/dL) for biliary atresia, per AAP. A, D-E are for indirect jaundice, B is invasive.

Question 3 of 5

A 3-month-old infant presents with apnea and cyanosis. EEG shows epileptiform activity. Most likely diagnosis is:

Correct Answer: C

Rationale: Seizure disorder fits apnea, cyanosis, and EEG findings, per AAP. A, B, D, E lack epileptiform activity.

Question 4 of 5

A 4-year-old boy presents with abdominal pain and a sausage-shaped mass. Ultrasound shows intussusception. The next step is:

Correct Answer: C

Rationale: Air enema is the first-line treatment for intussusception, per AAP. A, B, D, E are secondary.

Question 5 of 5

A 6-month-old infant presents with failure to thrive and hepatosplenomegaly. Labs show elevated triglycerides and uric acid. Most likely diagnosis is:

Correct Answer: B

Rationale: Niemann-Pick disease features failure to thrive, hepatosplenomegaly, and lipid abnormalities, per NORD. A, C-E have distinct profiles.

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