ATI LPN
NCLEX PN Pharmacology Practice Questions Questions
Question 1 of 9
Drugs that should be avoided in patients who are CYP2D6 ultrarapid metabolizers include:
Correct Answer: B
Rationale: Choice B is correct because CYP2D6 ultrarapid metabolizers convert codeine to morphine too quickly, risking overdose and toxicity, so it should be avoided. Choice A is incorrect as acetaminophen's metabolism isn't significantly CYP2D6-dependent, posing less risk. Choice C is wrong because ibuprofen isn't metabolized by CYP2D6, so ultrarapid status is irrelevant. Choice D is incorrect since only codeine poses a specific danger here.
Question 2 of 9
Drugs that should be avoided in patients who are CYP2D6 ultrarapid metabolizers include:
Correct Answer: B
Rationale: Choice B is correct because CYP2D6 ultrarapid metabolizers convert codeine to morphine too quickly, risking overdose and toxicity, so it should be avoided. Choice A is incorrect as acetaminophen's metabolism isn't significantly CYP2D6-dependent, posing less risk. Choice C is wrong because ibuprofen isn't metabolized by CYP2D6, so ultrarapid status is irrelevant. Choice D is incorrect since only codeine poses a specific danger here.
Question 3 of 9
Under new U.S. Food and Drug Administration labeling, Pregnancy Categories will be:
Correct Answer: B
Rationale: Choice B is correct because the FDA replaced letter categories (A, B, C, etc.) with detailed risk summaries and clinical considerations to better inform prescribing during pregnancy. Choice A is incorrect as no new coding like C+ exists. Choice C is wrong because categories aren't just linked to TOXNET—they're replaced with narrative data. Choice D is incorrect since trimester-specific dosages aren't the standard replacement.
Question 4 of 9
Women who have a history of venous thromboembolism should avoid:
Correct Answer: B
Rationale: Choice B is correct because estrogen increases clotting risk, so it's avoided in women with VTE history, per medical consensus. Choice A is incorrect as testosterone doesn't significantly raise VTE risk. Choice C is wrong because progesterone's risk is lower and not absolute. Choice D is incorrect since only estrogen is the key avoidance.
Question 5 of 9
An NP is prescribing a drug that is known to be safe in children but is unable to find recommendations about drug dosing. The recommended adult dose is $100 \mathrm{mg}$ per dose. The child weighs $14 \mathrm{~kg}$. Using Clark's rule, the NP should order __ mg per dose.
Correct Answer: A
Rationale: The correct answer is A because Clark’s rule (child’s weight in kg / 70 kg * adult dose) yields 14/70 * 100 = 20 mg. Choice B is incorrect (10 mg is too low). Choice C is wrong (14 mg doesn’t follow the rule). Choice D is inaccurate (9.3 mg is a miscalculation).
Question 6 of 9
Drugs that should be avoided in patients who are CYP2D6 ultrarapid metabolizers include:
Correct Answer: B
Rationale: Choice B is correct because CYP2D6 ultrarapid metabolizers convert codeine to morphine too quickly, risking overdose and toxicity, so it should be avoided. Choice A is incorrect as acetaminophen's metabolism isn't significantly CYP2D6-dependent, posing less risk. Choice C is wrong because ibuprofen isn't metabolized by CYP2D6, so ultrarapid status is irrelevant. Choice D is incorrect since only codeine poses a specific danger here.
Question 7 of 9
Herbal products that should be avoided when a patient is prescribed an antidepressant include:
Correct Answer: B
Rationale: Choice B is correct because St John's wort induces CYP3A4 and affects serotonin, risking reduced antidepressant efficacy or serotonin syndrome, so it's to be avoided. Choice A is incorrect as ginkgo biloba doesn't significantly interact with antidepressants. Choice C is wrong because valerian root's sedative effect is minor and not a major concern. Choice D is incorrect since only St John's wort poses a substantial risk.
Question 8 of 9
Which of the following statements is true about the prescribing practices of physicians?
Correct Answer: D
Rationale: The correct answer is D because studies show that despite physicians claiming reliance on academic sources, commercial drug information from pharmaceutical companies dominates their resources. Choice A is incorrect as younger physicians prescribe more appropriately. Choice B is wrong since antibiotics are no longer in the top five. Choice C is inaccurate because the average therapeutic armamentarium is about 144 drugs, not less than 100.
Question 9 of 9
A patient is seen in the clinic with a 1-week history of frequent watery stools. The primary care NP learns that a family member had gastroenteritis a week prior. The patient was treated for a UTI with a sulfonamide antibiotic 2 months prior. The NP should suspect:
Correct Answer: A
Rationale: The correct answer is A because CDAD can occur up to 2 months post-antibiotic, causing diarrhea. Choice B is incorrect (viral possible but CDAD priority). Choice C is wrong (serum sickness not diarrhea-related). Choice D is inaccurate (UTI unrelated).