ATI LPN
NCLEX PN Questions on Pharmacology Questions
Question 1 of 9
Drugs that may cause tolerance include:
Correct Answer: D
Rationale: Choice D is correct because benzodiazepines, opioids, and alcohol all cause tolerance, requiring higher doses for the same effect due to receptor adaptation, per pharmacology. Choice A is incorrect alone as it's one class. Choice B is wrong by itself because opioids are just part. Choice C is incorrect solo since alcohol is only one substance.
Question 2 of 9
An 80-year-old woman has chronically low hemoglobin despite a diet high in iron. The primary care nurse practitioner (NP) will perform laboratory tests to confirm a diagnosis and should suspect the patient will need:
Correct Answer: B
Rationale: The correct answer is B because elderly women are prone to folic acid deficiency, impairing hemoglobin synthesis despite iron intake. Choice A is incorrect (omega-3 unrelated). Choice C is wrong (multivitamin iron insufficient). Choice D is inaccurate (dietary folic acid less effective).
Question 3 of 9
An Investigational New Drug is filed with the U.S. Food and Drug Administration:
Correct Answer: D
Rationale: Choice D is correct because an IND filing is required before human testing (phase I trials) to ensure safety data from preclinical studies supports proceeding, per FDA rules. Choice A is incorrect as phase III completion is too late—IND precedes all human trials. Choice B is wrong because discovery alone doesn't trigger filing; preclinical data is needed. Choice C is incorrect since animal testing occurs before the IND, not after.
Question 4 of 9
Drugs that should not be split include:
Correct Answer: D
Rationale: Choice D is correct because enteric-coated tablets (altered absorption), extended-release formulations (disrupted timing), and capsules (uneven dosing) shouldn't be split, risking efficacy or toxicity. Choice A is incorrect alone as it's one type. Choice B is wrong by itself because extended-release is just part. Choice C is incorrect solo since capsules are only one category.
Question 5 of 9
A patient who takes warfarin (Coumadin) experiences excessive bleeding, even though serum drug levels are normal. The primary care NP should question this patient about the use of:
Correct Answer: D
Rationale: The correct answer is D because ginkgo biloba decreases blood viscosity, enhancing warfarin’s bleeding risk. Choices A, B, and C are incorrect as they don’t significantly affect bleeding with warfarin.
Question 6 of 9
Drugs that are metabolized by CYP2C9 include:
Correct Answer: A
Rationale: Choice A is correct because warfarin is metabolized by CYP2C9, and variants affect its dosing due to altered clearance rates, unlike the others. Choice B is incorrect as codeine uses CYP2D6, not CYP2C9, for activation. Choice C is wrong because acetaminophen is primarily glucuronidated, not CYP2C9-dependent. Choice D is incorrect since only warfarin fits this metabolic pathway.
Question 7 of 9
Prescription drugs that are commonly misused include:
Correct Answer: D
Rationale: Choice D is correct because opioids (e.g., oxycodone), benzodiazepines (e.g., alprazolam), and stimulants (e.g., Adderall) are frequently misused for euphoria or dependence, per DEA data. Choice A is incorrect alone as it's one class. Choice B is wrong by itself because benzos are just part. Choice C is incorrect solo since stimulants are only one group.
Question 8 of 9
Signs of drug abuse include:
Correct Answer: D
Rationale: Choice D is correct because drug abuse manifests as behavioral changes (e.g., irritability), physical signs (e.g., weight loss), and withdrawal (isolation), per addiction criteria. Choice A is incorrect alone as it's one sign. Choice B is wrong by itself because symptoms are just part. Choice C is incorrect solo since withdrawal is only one indicator.
Question 9 of 9
The therapeutic goals when prescribing include(s):
Correct Answer: D
Rationale: Choice D is correct because therapeutic goals can be curative (healing), palliative (symptom relief), or preventive (disease avoidance), depending on the patient's condition, making all options valid. Choice A is incorrect as it's only one goal, not all. Choice B is wrong because it excludes curative and preventive aims. Choice C is incorrect since it misses curative and palliative goals.