ATI PN Custom Pharmacology | Nurselytic

Correct Answer: D

Rationale: The correct answer is D: Drug interaction. Drug interaction occurs when one drug affects the pharmacokinetics or pharmacodynamics of another drug. In this case, the antacid inhibits the dissolution of ketoconazole, leading to a potential decrease in its absorption. This can result in reduced therapeutic effects or increased side effects of ketoconazole.

A: Allergic reaction - This choice is incorrect as an allergic reaction involves the body's immune response to a drug, not a physical interaction between drugs.
B: Displacement - This choice is incorrect as displacement refers to one drug displacing another from protein binding sites, not inhibiting dissolution.
C: Accumulation - This choice is incorrect as accumulation refers to the build-up of a drug in the body over time, not an immediate interaction between drugs.

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