Correct Answer: D

Rationale: The effectiveness of amiodarone is best assessed by a reduction in irregular heartbeats, as it is primarily used to treat ventricular dysrhythmias. Angina spells, ankle swelling, and cholesterol levels are not direct indicators of amiodarone's effectiveness.

Correct Answer: A

Rationale: The correct answer is A: Increased risk of bleeding. Edoxaban is an anticoagulant that works by inhibiting clot formation, thereby increasing the risk of bleeding. Therefore, the nurse should closely monitor the client for signs of bleeding, such as bruising, petechiae, hematuria, or gastrointestinal bleeding, to prevent potential complications.

Correct Answer: B

Rationale: To accurately determine peak and trough levels of vancomycin, blood should be drawn two hours after the completion of the IV dose and 30 minutes before the next dose. This timing allows for appropriate assessment of the drug levels in the body, ensuring accurate monitoring of therapeutic and toxic concentrations.

Correct Answer: C

Rationale: To assess the effectiveness of the medication for anemia in a client with CKD, monitoring hemoglobin levels is crucial. Hemoglobin levels serve as a direct indicator of the response to treatment and improvement in the condition. An increase in hemoglobin level to 12 grams/dL suggests that the medication is effectively addressing the anemia associated with CKD.

Correct Answer: A

Rationale: The correct answer is A: Increased risk of infection. Infliximab is known to increase the risk of infection due to its immunosuppressive effects. It is crucial for the nurse to monitor for signs of infection in the client receiving infliximab to promptly address any potential complications and ensure the client's safety and well-being.