Correct Answer: C

Rationale: The passage discusses the challenges and symptoms associated with sickle-cell anemia, portraying a somber and serious tone. The descriptions of persistent pain, difficulties, and the impact on individuals' lives make the overall tone fairly grim. The essay focuses on the hardships faced by individuals with sickle-cell anemia, highlighting the severity of the disease. Choices A, B, and D are incorrect because the tone of the essay is not informal, insensitive, or uplifting. It is important to consider the language used, the subject matter, and the overall emotional impact of the text to determine the tone accurately.

Correct Answer: B

Rationale: The correct answer is B. The passage clearly states that there are treatments for hypertension, so the statement that there is presently no reliable treatment for hypertension cannot be inferred from the text. Choice A can be inferred from paragraph 3 where it mentions losing weight to decrease blood pressure. Choice C can be inferred from paragraph 1 where it states that African Americans are more likely to have hypertension. Choice D can be inferred from paragraph 2 where it explains that older people are most often diagnosed with hypertension due to changes in blood vessels as they age.

Correct Answer: A

Rationale: Skim the passage to identify the detail that does not appear. The sports in choice A are never mentioned, so you do not even need to look at the other choices.

Correct Answer: C

Rationale: This is an opinion because it is a subjective statement about taste.

Correct Answer: D

Rationale: The title 'The Debate over Barefoot Running' captures the main discussion in the passage.