Correct Answer: A

Rationale: The word 'adverse' in the sentence is most closely aligned with the meaning of 'unfavorable.' An adverse reaction to a medicine signifies a negative or harmful response, which supports the definition of unfavorable. Choice B, 'Contrary,' does not accurately capture the negative connotation associated with 'adverse.' Choice C, 'Noticeable,' does not reflect the meaning in the context provided. Choice D, 'Startling,' suggests a more sudden or surprising nature, which is not the primary meaning of 'adverse' in this context.

Correct Answer: A

Rationale: The abbreviation PDR stands for Physician's Desk Reference, which is a widely used book containing information about prescription drugs, including their uses, side effects, and dosages. Therefore, the abbreviation PDR is associated with drugs. Choices B, C, and D are incorrect because PDR specifically relates to drugs and not procedures, books, or muscle groups.

Correct Answer: A

Rationale: The word 'simulated' means to imitate or replicate the characteristics or actions of something. It involves creating a representation that resembles the original. In this context, 'imitated' is the correct synonym as it aligns with the idea of mimicking or reproducing something to simulate it. Choices B, C, and D are incorrect as they do not reflect the concept of imitation or replication, which is central to the meaning of 'simulated.'

Correct Answer: D

Rationale: The term 'doleful' is best described as feeling or expressing sorrow or sadness. 'Downcast' aligns with this meaning as it refers to having a dejected or low spirit, which matches the nature of doleful. Options A, B, and C do not directly relate to the sense of sadness or sorrow that doleful conveys. 'Unwell' means in poor health, 'deprived' means lacking something essential, and 'conceited' means having an excessively favorable opinion of oneself, none of which capture the essence of doleful.

Correct Answer: C

Rationale: Enervated refers to being weakened or lacking energy, so an enervated patient would likely be fatigued or tired. This term does not specifically imply anxiety, immaturity, or fear, making 'tired' the most suitable choice in this context. 'Anxious' (choice A) means feeling nervous or worried, which is not directly related to being enervated. 'Immature' (choice B) refers to lacking maturity or development, which is unrelated to the patient's energy level. 'Frightened' (choice D) means feeling afraid or scared, which is not necessarily connected to being enervated.