RN HESI Pharmacology Exam 3

Extract:

Question 1 of 5

A client who received a renal transplant three months ago is readmitted to the acute care unit with signs of graft rejection. While taking the client's history, the nurse determines that the client has been self-administering St. John's Wort, an herbal preparation, on the advice of a friend. Which information is most significant about this finding?

A. Adding the herb can decrease the need for corticosteroids. B. The client probably used this herb to treat depression. C. Ingestion of St. John's Wort can reduce the client's intake of sodium. D. St. John's Wort can decrease plasma concentrations of cyclosporine.

Correct Answer: D

Rationale: St. John's Wort induces liver enzymes (CYP3A4), reducing cyclosporine levels, an immunosuppressant critical for preventing transplant rejection. This interaction increases rejection risk, making it the most significant finding. Corticosteroid needs, depression, or sodium intake are less critical.

Question 2 of 5

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RN HESI Pharmacology Exam 3 | Nurselytic

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