HESI RN
Wgu HESI RN Pharmacology 1 Questions
Extract:
Question 1 of 5
A client who received a renal transplant three months ago is readmitted to the acute care unit with signs of graft rejection. While taking the client's history, the nurse determines that the client has been self-administering St. John's Wort, an herbal preparation, on the advice of a friend. Which information is most significant about this finding?
Correct Answer: C
Rationale: St. John's Wort induces liver enzymes (CYP3A4), reducing cyclosporine levels, an immunosuppressant critical for preventing transplant rejection. This interaction increases rejection risk, making it the most significant finding. Corticosteroid needs, sodium intake, or depression are less critical.
Question 2 of 5
A client who is newly diagnosed with diabetes insipidus (DI) is receiving a synthetic vasopressin intravenously. Which side effect of vasopressin reported by the client should the nurse report to the healthcare provider?
Correct Answer: A
Rationale: Worsening headache may indicate water intoxication or hyponatremia from excessive vasopressin-induced water retention, requiring immediate provider notification. Polyuria, low specific gravity, and polydipsia are DI symptoms, not vasopressin side effects.
Question 3 of 5
The nurse is providing medication teaching to a client with bipolar disorder who receives a prescription for lithium carbonate. Which instruction should the nurse emphasize with the client?
Correct Answer: C
Rationale: Adequate fluid intake (1500-3000 mL/day) prevents dehydration, which can elevate lithium levels and risk toxicity. Taking with food, reviewing fliers, or reporting weight changes are less critical to lithium safety.
Question 4 of 5
A client receives a prescription for allopurinol. Which information provided by the client requires additional instruction by the nurse?
Correct Answer: A
Rationale: Doubling a missed allopurinol dose risks toxicity and is incorrect; clients should take it as soon as remembered or skip it if near the next dose. Reducing caffeine/acidic intake, taking with food, and hydration are appropriate to manage uric acid and GI effects.
Question 5 of 5
Which action should the nurse implement to assess the effectiveness of amlodipine?
Correct Answer: B
Rationale: Amlodipine, a calcium channel blocker, lowers blood pressure to manage hypertension. Measuring blood pressure directly assesses its effectiveness. Electrolytes, intake/output, or calcium levels are not primary indicators of amlodipine’s therapeutic effect.