ATI LPN
Roach's Introductory Clinical Pharmacology 11th Edition
Chapter 21 Questions
Question 1 of 5
A nurse caring for a client taking amitriptyline for depression should monitor the client for which of the following adverse events?
Correct Answer: A,D,E
Rationale: Tricyclic antidepressants like amitriptyline commonly cause sedation, dry mouth, and photosensitivity as side effects due to their anticholinergic and antihistaminic properties.
Question 2 of 5
When describing the action of antidepressants, the nursing instructor would include the belief that they exert their effect by causing slow adaptive changes to which of the following receptor systems?
Correct Answer: C,D
Rationale: Antidepressants, particularly those affecting monoamine systems, induce adaptive changes in norepinephrine and serotonin receptor systems, enhancing neurotransmission over time.
Question 3 of 5
After teaching a group of nursing students about the action of antidepressants, the instructor determines that the teaching was successful when the students identify which of the following classes as exerting their effects by inhibiting reuptake of norepinephrine and serotonin?
Correct Answer: A,C
Rationale: Tricyclic antidepressants like amitriptyline and clomipramine inhibit the reuptake of norepinephrine and serotonin, increasing their availability in the synaptic cleft.
Question 4 of 5
Which of the following antidepressants exert their effects by inhibiting the reuptake of serotonin?
Correct Answer: D,E
Rationale: Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine and escitalopram specifically target serotonin reuptake, enhancing serotonin levels in the brain.
Question 5 of 5
A nurse administers amitriptyline cautiously to which clients?
Correct Answer: A,D
Rationale: Amitriptyline's anticholinergic and cardiac effects necessitate caution in clients with cardiac disease and elderly clients, who are more sensitive to these effects.